MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1 | Zendy

Bin Zhou | Zendy; Chuandong Sun | Zendy; Xiao Hu | Zendy; Hanxiang Zhan | Zendy; Hao Zou | Zendy; Yujie Feng | Zendy; Fabo Qiu | Zendy; Shun Zhang | Zendy; Liqun Wu | Zendy; Bingyuan Zhang | Zendy

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MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1

Author(s) -

Bin Zhou,

Chuandong Sun,

Xiao Hu,

Hanxiang Zhan,

Hao Zou,

Yujie Feng,

Fabo Qiu,

Shun Zhang,

Liqun Wu,

Bingyuan Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485876

Subject(s) - cancer research , pancreatic cancer , microrna , metastasis , biology , cell cycle , cell growth , western blot , cancer , gene , biochemistry , genetics

Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor-specific stem cell marker in pancreatic cancer (PC). MicroRNA-195 (miR-195) plays an important role in many types of tumors. However, the roles of DCLK1 in cancer and miRNAs that directly regulate DCLK1 have not been elucidated. The goal of this study is to assess the effects of miR-195 on inhibiting DCLK1 and to clarify the regulating mechanism of miR-195-DCLK1 in PC cells.

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