Human Leukocyte Antigen-G Inhibits the Anti-Tumor Effect of Natural Killer Cells via Immunoglobulin-Like Transcript 2 in Gastric Cancer | Zendy

Rui Wan | Zendy; Ziwei Wang | Zendy; Hui Li | Zendy; Xudong Peng | Zendy; Guangyi Liu | Zendy; Jun-Ming Ou | Zendy; Anqi Cheng | Zendy

Open Access

Human Leukocyte Antigen-G Inhibits the Anti-Tumor Effect of Natural Killer Cells via Immunoglobulin-Like Transcript 2 in Gastric Cancer

Author(s) -

Rui Wan,

Ziwei Wang,

Hui Li,

Xudong Peng,

Guangyi Liu,

Jun-Ming Ou,

Anqi Cheng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485819

Subject(s) - cytotoxic t cell , flow cytometry , natural killer cell , biology , antibody , microbiology and biotechnology , human leukocyte antigen , hla g , immunohistochemistry , immune system , antigen , cancer research , cell culture , chemistry , immunology , in vitro , biochemistry , genetics

Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK in gastric cancer (GC) remains not well understood. This study investigated the expression of HLA-G in GC and the role of HLA-G-effected NK cells in GC progression.

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