Repeated Combined Chemotherapy with Cisplatin Lowers Carnitine Levels in Gastric Cancer Patients | Zendy

A. Kawai | Zendy; Hideo Matsumoto | Zendy; Youko Endou | Zendy; Yui Honda | Zendy; Hisako Kubota | Zendy; Masaharu Higashida | Zendy; Toshihiro Hirai | Zendy

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Repeated Combined Chemotherapy with Cisplatin Lowers Carnitine Levels in Gastric Cancer Patients

Author(s) -

A. Kawai,

Hideo Matsumoto,

Youko Endou,

Yui Honda,

Hisako Kubota,

Masaharu Higashida,

Toshihiro Hirai

Publication year - 2017

Publication title -

annals of nutrition and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.926

H-Index - 81

eISSN - 1421-9697

pISSN - 0250-6807

DOI - 10.1159/000485808

Subject(s) - carnitine , medicine , chemotherapy , gastroenterology , cisplatin , cancer , endocrinology

Carnitine plays an important role in the metabolism of fatty acids. It has also been reported that the administration of anticancer drugs may lead to reductions in serum carnitine levels due to decreased activity of organic cation transporter novel 2, which plays a role in the reabsorption of carnitine in the tubules of the kidney. We therefore studied the change in carnitine levels when chemotherapy was administered repeatedly to patients with gastric cancer.

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