Rapamycin Promotes the Survival and Adipogenesis of Ischemia-Challenged Adipose Derived Stem Cells by Improving Autophagy | Zendy

Chichi Li | Zendy; Lechi Ye | Zendy; Li Yang | Zendy; Xiaofang Yu | Zendy; Yucang He | Zendy; Zhuojie Chen | Zendy; Liqun Li | Zendy; Dan Zhang | Zendy

Open Access

Rapamycin Promotes the Survival and Adipogenesis of Ischemia-Challenged Adipose Derived Stem Cells by Improving Autophagy

Author(s) -

Chichi Li,

Lechi Ye,

Li Yang,

Xiaofang Yu,

Yucang He,

Zhuojie Chen,

Liqun Li,

Dan Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485783

Subject(s) - autophagy , adipogenesis , microbiology and biotechnology , oil red o , pi3k/akt/mtor pathway , small hairpin rna , tunel assay , adipose tissue , apoptosis , biology , chemistry , endocrinology , signal transduction , gene knockdown , biochemistry

Ischemia is one of the main causes of the high rate of absorption of transplanted autologous fat. Autophagy allows cells to survive by providing energy under starvation. Rapamycin has been found to play a role in promoting autophagy. In this study, we investigated whether rapamycin participates in the survival and adipogenesis of ischemia-challenged adipose-derived stem cells (ADSCs) by regulating autophagy.

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