Proteomic Analysis Reveals Grb2 as a Key Regulator of Periodic Mechanical Stress Transduction in Chondrocytes | Zendy

Shun Xu | Zendy; Li Zeng | Zendy; Zhen Wang | Zendy; Chenjun Zhai | Zendy; Wenwei Liang | Zendy; Chunhui Zhu | Zendy; Weimin Fan | Zendy

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Proteomic Analysis Reveals Grb2 as a Key Regulator of Periodic Mechanical Stress Transduction in Chondrocytes

Author(s) -

Shun Xu,

Li Zeng,

Zhen Wang,

Chenjun Zhai,

Wenwei Liang,

Chunhui Zhu,

Weimin Fan

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485646

Subject(s) - mechanotransduction , focal adhesion , microbiology and biotechnology , chondrocyte , integrin , proteome , signal transduction , extracellular matrix , phosphorylation , western blot , regulator , biology , kinase , grb2 , chemistry , cartilage , receptor , bioinformatics , biochemistry , anatomy , signal transducing adaptor protein , gene

Periodic mechanical stress could significantly promote chondrocyte proliferation and matrix synthesis. However, the mechanisms underlying the ability of chondrocyte detecting and responding to periodic mechanical stimuli have not been well delineated.

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