TREM-1 Contributes to Inflammation in IgA Nephropathy | Zendy

Yanfeng Zhao | Zendy; Li Zhu | Zendy; Lijun Liu | Zendy; Sufang Shi | Zendy; Jicheng Lv | Zendy; Hong Zhang | Zendy

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TREM-1 Contributes to Inflammation in IgA Nephropathy

Author(s) -

Yanfeng Zhao,

Li Zhu,

Lijun Liu,

Sufang Shi,

Jicheng Lv,

Hong Zhang

Publication year - 2018

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000485622

Subject(s) - inflammation , nephropathy , urinary system , medicine , glomerulonephritis , mesangial cell , immunology , cytokine , kidney , downregulation and upregulation , mesangial proliferative glomerulonephritis , pathogenesis , endocrinology , biology , gene , biochemistry , diabetes mellitus

Circulating IgA1-containing immune complexes (cIgA1) were shown to play important roles in IgA nephropathy (IgAN). They could induce the release of multiple inflammatory factors, including MCP-1 and IL-6, and elevated urinary inflammatory factors were also reported in patients with IgAN, which suggested that inflammation is a major contributor to kidney injury in IgAN. After the previous identification of the upregulated release of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) by mesangial cells under cIgA1 challenge using cytokine array, in the present study, we further explored the role of TREM-1, an amplifier of inflammation, in cIgA1-induced kidney injury.

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