Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases | Zendy

Bharath Chelluboina | Zendy; Koteswara Rao Nalamolu | Zendy; Gustavo G. Mendez | Zendy; Jeffrey D. Klopfenstein | Zendy; David M. Pinson | Zendy; David Z. Wang | Zendy; Krishna Kumar Veeravalli | Zendy

Open Access

Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Author(s) -

Bharath Chelluboina,

Koteswara Rao Nalamolu,

Gustavo G. Mendez,

Jeffrey D. Klopfenstein,

David M. Pinson,

David Z. Wang,

Krishna Kumar Veeravalli

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485533

Subject(s) - matrix metalloproteinase , mesenchymal stem cell , medicine , downregulation and upregulation , stem cell , ischemia , brain ischemia , pathology , immunology , cancer research , biology , microbiology and biotechnology , biochemistry , gene

Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) in a rat model of ischemic stroke. The treatment attenuated apoptosis and prevented DNA damage. A collection of published studies, including several from our laboratory, indicated the induction and detrimental role for several matrix metalloproteinases (MMPs) in post-stroke brain injury. We hypothesized that the HUCB-MSCs treatment after focal cerebral ischemia prevents the dysregulation of MMPs and induces the expression of endogenous tissue inhibitors of metalloproteinases (TIMPs) to neutralize the elevated activity of MMPs.

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