Mechanosensitivity of Embryonic Neurites Promotes Their Directional Extension and Schwann Cells Progenitors Migration | Zendy

Gonzalo Rosso | Zendy; Peter Young | Zendy; Victor Shahin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanosensitivity of Embryonic Neurites Promotes Their Directional Extension and Schwann Cells Progenitors Migration

Author(s) -

Gonzalo Rosso,

Peter Young,

Victor Shahin

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485485

Subject(s) - neurite , embryonic stem cell , microbiology and biotechnology , regeneration (biology) , neuroscience , progenitor cell , extracellular matrix , biology , anatomy , stem cell , in vitro , biochemistry , gene

Migration of Schwann cells (SCs) progenitors and neurite outgrowth from embryonic dorsal root ganglions (DRGs) are two central events during the development of the peripheral nervous system (PNS). How these two enthralling events preceding myelination are promoted is of great relevance from basic research and clinical aspects alike. Recent evidence demonstrates that biophysical cues (extracellular matrix stiffness) and biochemical signaling act in concert to regulate PNS myelination. Microenvironment stiffness of SCs progenitors and embryonic neurites dynamically changes during development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research