Cardiomyopathy-Associated Gene 1-Sensitive PKC-Dependent Connexin 43 Expression and Phosphorylation in Left Ventricular Noncompaction Cardiomyopathy
Author(s) -
Yuanyuan Xie,
Shenghua Liu,
Shengshou Hu,
Yingjie Wei
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485348
Subject(s) - cardiomyopathy , connexin , intercalated disc , pathogenesis , biology , phosphorylation , gap junction , signal transduction , microbiology and biotechnology , blot , medicine , protein kinase c , gene expression , endocrinology , cancer research , intracellular , heart failure , gene , immunology , genetics
Cardiomyopathy-associated gene 1 (CMYA1) plays an important role in embryonic cardiac development, postnatal cardiac remodeling and myocardial injury repair. Abnormal CMYA1 expression may be involved in cardiac dysplasia and primary cardiomyopathy. Our study aims to establish the relationship between CMYA1 and Left ventricular noncompaction cardiomyopathy (LVNC) pathogenesis.
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