Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells | Zendy

PeiFeng Liu | Zendy; Chien-Jen Hsu | Zendy; WeiLun Tsai | Zendy; JinShiung Cheng | Zendy; JihJung Chen | Zendy; IFei Huang | Zendy; HoHsing Tseng | Zendy; HsuehWei Chang | Zendy; ChihWen Shu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells

Author(s) -

PeiFeng Liu,

Chien-Jen Hsu,

WeiLun Tsai,

JinShiung Cheng,

JihJung Chen,

IFei Huang,

HoHsing Tseng,

HsuehWei Chang,

ChihWen Shu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485286

Subject(s) - ampk , cancer cell , gene knockdown , autophagy , biology , cell growth , cell cycle , microbiology and biotechnology , protein kinase a , cancer research , chemistry , cell , kinase , apoptosis , cancer , biochemistry , genetics

ATG4B is a cysteine protease required for autophagy, which is a cellular catabolic pathway involved in energy balance. ATG4B expression is elevated during tumor growth in certain types of cancer, suggesting that ATG4B is an attractive target for cancer therapy. However, little is known about the mechanisms through which ATG4B deprivation suppresses the growth of cancer cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research