Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension | Zendy

Ning Zhou | Zendy; JiaJye Lee | Zendy; Shaunrick Stoll | Zendy; Ben Ma | Zendy; Kevin D. Costa | Zendy; Hongyu Qiu | Zendy

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Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

Author(s) -

Ning Zhou,

JiaJye Lee,

Shaunrick Stoll,

Ben Ma,

Kevin D. Costa,

Hongyu Qiu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485284

Subject(s) - myocardin , serum response factor , vascular smooth muscle , rho associated protein kinase , medicine , endocrinology , actin , chemistry , aorta , microbiology and biotechnology , anatomy , biology , smooth muscle , signal transduction , biochemistry , gene expression , gene

Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown. We here hypothesized that Rho kinase (ROCK) acts as a novel mediator that regulates intrinsic VSMC mechanical properties through the serum response factor (SRF) /myocardin pathway and consequently regulates aortic stiffness and blood pressure in hypertension.

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