Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma | Zendy

Tao Liu | Zendy; Chanji Wu | Zendy; Guohu Weng | Zendy; Zhongyan Zhao | Zendy; Xiangying He | Zendy; Chuanyi Fu | Zendy; Zhiyan Sui | Zendy; Shixiong Huang | Zendy

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Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma

Author(s) -

Tao Liu,

Chanji Wu,

Guohu Weng,

Zhongyan Zhao,

Xiangying He,

Chuanyi Fu,

Zhiyan Sui,

Shixiong Huang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485279

Subject(s) - bufalin , cell growth , apoptosis , viability assay , cell , cell cycle , glioma , transfection , downregulation and upregulation , cancer research , microrna , biology , neurosphere , chemistry , microbiology and biotechnology , cell culture , cellular differentiation , adult stem cell , biochemistry , gene , genetics

Prior studies have shown that bufalin inhibits cellular proliferation and induces apoptosis in various human cancers. MicroRNA-203 (miR-203) has been shown to function as an important regulator of tumor progression at various stages. In this study, we investigated the effect of miR-203 expression and bufalin treatment on glioma cell proliferation and stem cell-like phenotypes.

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