Open AccessAssociation of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis
Author(s) -
Jan M. HughesAustin,
Ryan W. Gan,
Kevin D. Deane,
Michael H. Weisman,
M. Kristen Demoruelle,
Jeremy Sokolove,
William H. Robinson,
V. Michael Holers,
Jill M. Norris,
Joachim H. Ix
Publication year - 2017
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000485259
Subject(s) - medicine , first degree relatives , rheumatoid arthritis , autoantibody , population , blood pressure , immunology , body mass index , rheumatoid factor , antibody , gastroenterology , family history , environmental health
Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications. We hypothesized that a greater number of detectable ACPA would be associated with high SBP and DBP, independent of other risk factors in these first-degree relatives.
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