MicroRNA Expression Profiling of Pancreatic Cancer Cell Line L3.6p1 Following B7-H4 Knockdown
Author(s) -
Yun Qian,
Limin Feng,
Weigen Wu,
Tian-Hao Weng,
Chen-Yu Hu,
Bo Hong,
Frederick X.C. Wang,
Lingwei Shen,
Qi Wang,
Xin Jin,
HangPing Yao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000485086
Subject(s) - pancreatic cancer , microrna , biology , cancer research , pi3k/akt/mtor pathway , protein kinase b , gene knockdown , kegg , signal transduction , transfection , metastasis , cancer , cell culture , gene expression , microbiology and biotechnology , gene , genetics , transcriptome
Co-stimulating molecule B7-H4 regulates T cell-mediated immune responses, participates in tumor immune escape, and promotes the proliferation and metastasis of pancreatic cancer cells. However, the specific mechanisms are unclear. MicroRNAs (miRNAs) participated in the pathogenesis and progression of cancer.
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