Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction | Zendy

Krishna M. Boini | Zendy; Tahir Hussain | Zendy; PinLan Li | Zendy; Sai S. Koka | Zendy

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Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

Author(s) -

Krishna M. Boini,

Tahir Hussain,

PinLan Li,

Sai S. Koka

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484623

Subject(s) - inflammasome , chemistry , trimethylamine n oxide , microbiology and biotechnology , caspase 1 , foam cell , biochemistry , trimethylamine , biology , in vitro , macrophage , receptor

Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism of dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk of cardiovascular diseases (CVD) in rodents and humans. However, the molecular mechanisms of how TMAO induces atherosclerosis and CVD progression are still unclear. The present study tested whether TMAO induces NLRP3 inflammasome formation and activation and thereby contributes to endothelial injury initiating atherogenesis.

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