MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes | Zendy

Guping Mao | Zendy; Peihui Wu | Zendy; Ziji Zhang | Zendy; Zhiqi Zhang | Zendy; WeiMing Liao | Zendy; Yukang Li | Zendy; Yan Kang | Zendy

Open Access

MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes

Author(s) -

Guping Mao,

Peihui Wu,

Ziji Zhang,

Zhiqi Zhang,

WeiMing Liao,

Yukang Li,

Yan Kang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484579

Subject(s) - aggrecanase , chondrogenesis , microrna , microbiology and biotechnology , catabolism , chemistry , biology , articular cartilage , medicine , biochemistry , osteoarthritis , enzyme , mesenchymal stem cell , gene , pathology , alternative medicine

Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family that play significant roles in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5 in chondrogenesis and inflammation is regulated by microRNA-92a-3p (miR-92a-3p).

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