Deferoxamine-Induced Migration and Odontoblast Differentiation via ROS-Dependent Autophagy in Dental Pulp Stem Cells | Zendy

Xuan Wang | Zendy; Tian Tian Wu | Zendy; Long Jiang | Zendy; Rong Du | Zendy; Ya Qin Zhu | Zendy

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Deferoxamine-Induced Migration and Odontoblast Differentiation via ROS-Dependent Autophagy in Dental Pulp Stem Cells

Author(s) -

Xuan Wang,

Tian Tian Wu,

Long Jiang,

Rong Du,

Ya Qin Zhu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484506

Subject(s) - dental pulp stem cells , odontoblast , autophagy , deferoxamine , stem cell , microbiology and biotechnology , chemistry , pulp (tooth) , medicine , biology , dentistry , apoptosis , biochemistry

As a vital degradation and recycling system, autophagy plays an essential role in regulating the differentiation of stem cells. We previously showed that iron chelator deferoxamine (DFO) could promote the repair ability of dental pulp stem cells (DPSCs). Here, we investigated the effect of DFO in autophagy and the role of autophagy in regulating the migration and odontoblast differentiation of DPSCs.

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