Open AccessMaternally Expressed Gene 3 (MEG3) Enhances PC12 Cell Hypoxia Injury by Targeting MiR-147
Author(s) -
Lili Han,
Zhiling Dong,
Ningning Liu,
Fei Xie,
Ning Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000484452
Subject(s) - hypoxia (environmental) , gene expression , chemistry , gene , microbiology and biotechnology , biology , medicine , biochemistry , oxygen , organic chemistry
Cerebral ischemia often leads to breakdown of blood-brain barrier (BBB) and vasogenic edema. It remains to be established whether MEG3 is responsible for the hypoxic damage in neural cells. This study aimed to investigate the role of MEG3 in the hypoxia-induced injuries of PC12 cells.
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