Lymphoproliferative Disorders in Inflammatory Bowel Disease Patients: Is It the Drugs or the Disease | Zendy

Carlos Bernardes | Zendy; Pedro Russo | Zendy; Diana Carvalho | Zendy; Joana Saiote | Zendy; Jaime Ramos | Zendy

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Lymphoproliferative Disorders in Inflammatory Bowel Disease Patients: Is It the Drugs or the Disease

Author(s) -

Carlos Bernardes,

Pedro Russo,

Diana Carvalho,

Joana Saiote,

Jaime Ramos

Publication year - 2017

Publication title -

ge portuguese journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 9

eISSN - 2341-4545

pISSN - 2387-1954

DOI - 10.1159/000484440

Subject(s) - medicine , lymphoproliferative disorders , inflammatory bowel disease , lymphoma , disease , gastroenterology , population , immunology , environmental health

Systemic inflammatory diseases are related to an increased risk of lymphoproliferative disorders. Although inflammatory bowel disease (IBD) was also associated with these conditions, population-based studies failed to demonstrate this relationship, and most studies only identified a very small number of cases. In the last few years, concerns arose regarding the role of thiopurines and tumour necrosis factor-alpha (TNF-α)-blocking agents in the development of lymphoma, influencing therapeutic decisions in IBD patients. The aim of this study was to describe a case series of IBD patients who developed a lymphoproliferative disorder in our tertiary referral centre.

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