Combination of Solamargine and Metformin Strengthens IGFBP1 Gene Expression Through Inactivation of Stat3 and Reciprocal Interaction Between FOXO3a and SP1 | Zendy

Qing Tang | Zendy; Fang Zheng | Zendy; Jingjing Wu | Zendy; Qian Xiao | Zendy; Liuning Li | Zendy; Swei Sunny Hann | Zendy

Open Access

Combination of Solamargine and Metformin Strengthens IGFBP1 Gene Expression Through Inactivation of Stat3 and Reciprocal Interaction Between FOXO3a and SP1

Author(s) -

Qing Tang,

Fang Zheng,

Jingjing Wu,

Qian Xiao,

Liuning Li,

Swei Sunny Hann

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484383

Subject(s) - stat3 , stat protein , gene silencing , cell growth , biology , activator (genetics) , microbiology and biotechnology , transfection , cancer research , western blot , phosphorylation , cell culture , receptor , biochemistry , gene , genetics

Solamargine, one natural photochemical component from traditional plants, has been shown to have anti-cancers properties. We previously showed that solamargine inhibited the growth of non-small-cell lung cancer (NSCLC) cells through suppression of prostaglandin E2 (PGE2) receptor EP4 gene and regulation of downstream signaling pathways. However, the detailed mechanism underlying this, especially in combination of metformin, a known AMPK activator, still remained to be determined.

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