Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2 | Zendy

Fujun Yu | Zendy; Bicheng Chen | Zendy; XuFei Fan | Zendy; Guojun Li | Zendy; Peihong Dong | Zendy; Jianjian Zheng | Zendy

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Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2

Author(s) -

Fujun Yu,

Bicheng Chen,

XuFei Fan,

Guojun Li,

Peihong Dong,

Jianjian Zheng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484303

Subject(s) - hepatic stellate cell , microrna , fibrosis , transforming growth factor , hepatic fibrosis , downregulation and upregulation , cancer research , chemistry , luciferase , microbiology and biotechnology , medicine , biology , transfection , gene , biochemistry

Recently, microRNAs (miRNAs) have been demonstrated to act as regulators of activation of hepatic stellate cells (HSCs). It is well known that the main profibrogenic inducer transforming growth factor-β1 (TGF-β1) contributes to HSC activation, which is a key event in liver fibrosis. Increasing studies show that miR-9-5p is down-regulated in liver fibrosis and restoration of miR-9-5p limits HSC activation. However, the role of miR-9-5p in TGF-β1-induced HSC activation is still not clear.

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