The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly | Zendy

YanNing Rui | Zendy; Zhen Xu | Zendy; Xiaoqian Fang | Zendy; Miriam R. Menezes | Zendy; Julien Balzeau | Zendy; Airu Niu | Zendy; John P. Hagan | Zendy; Dong Kim | Zendy

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The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly

Author(s) -

YanNing Rui,

Zhen Xu,

Xiaoqian Fang,

Miriam R. Menezes,

Julien Balzeau,

Airu Niu,

John P. Hagan,

Dong Kim

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484298

Subject(s) - focal adhesion , vinculin , microbiology and biotechnology , endosome , endocytosis , biology , cell adhesion , integrin , signal transduction , intracellular , cell , biochemistry

We recently discovered that harmful variants in THSD1 (Thrombospondin type-1 domain-containing protein 1) likely cause intracranial aneurysm and subarachnoid hemorrhage in a subset of both familial and sporadic patients with supporting evidence from two vertebrate models. The current study seeks to elucidate how THSD1 and patient-identified variants function molecularly in focal adhesions.

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