Long Interspersed Element-1 Methylation Level as a Prognostic Biomarker in Gastrointestinal Cancers | Zendy

Yoshifumi Baba | Zendy; Taisuke Yagi | Zendy; Hiroshi Sawayama | Zendy; Yukiharu Hiyoshi | Zendy; Takatsugu Ishimoto | Zendy; Masaaki Iwatsuki | Zendy; Yuji Miyamoto | Zendy; Naoya Yoshida | Zendy; Hideo Baba | Zendy

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Long Interspersed Element-1 Methylation Level as a Prognostic Biomarker in Gastrointestinal Cancers

Author(s) -

Yoshifumi Baba,

Taisuke Yagi,

Hiroshi Sawayama,

Yukiharu Hiyoshi,

Takatsugu Ishimoto,

Masaaki Iwatsuki,

Yuji Miyamoto,

Naoya Yoshida,

Hideo Baba

Publication year - 2018

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000484104

Subject(s) - dna methylation , epigenetics , methylation , biology , cpg site , biomarker , cancer research , promoter , epigenomics , cancer epigenetics , genetics , cancer , gene , gene expression

Epigenetic changes play a crucial role in human cancer development. DNA methylation is a central epigenetic process that regulates levels of gene expression. Changes in DNA methylation that occur in human tumors include global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Long interspersed element-1 (LINE-1) is a repetitive DNA retrotransposon that duplicates via a copy-and-paste genetic mechanism. As LINE-1 constitutes approximately 17% of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation. In a variety of gastrointestinal (GI) cancers, LINE-1 hypomethylation is strongly associated with a poor prognosis, supporting its potential role as a prognostic biomarker. In this article, we summarize current knowledge regarding LINE-1 methylation and its prognostic impact in GI cancers.

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