Luteolin Promotes Cell Apoptosis by Inducing Autophagy in Hepatocellular Carcinoma | Zendy

Zhijia Cao | Zendy; Huainian Zhang | Zendy; Xiaoyan Cai | Zendy; Wei Fang | Zendy; Dong Chai | Zendy; Ying Wen | Zendy; Hongsheng Chen | Zendy; Fujiang Chu | Zendy; Yongli Zhang | Zendy

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Luteolin Promotes Cell Apoptosis by Inducing Autophagy in Hepatocellular Carcinoma

Author(s) -

Zhijia Cao,

Huainian Zhang,

Xiaoyan Cai,

Wei Fang,

Dong Chai,

Ying Wen,

Hongsheng Chen,

Fujiang Chu,

Yongli Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000484066

Subject(s) - autophagy , apoptosis , hepatocellular carcinoma , luteolin , cancer research , microbiology and biotechnology , programmed cell death , cell , chemistry , cell growth , biology , medicine , biochemistry , flavonoid , antioxidant

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Luteolin, a flavonoid from traditional Chinese medicine, shows anti-cancer activity in many cancer cells, including HCC. However, the mechanism underlying the action of luteolin in HCC, especially its role in regulating cell autophagy, remains unclear. In the present study, we investigated the role of luteolin in regulating cell autophagy and the role of autophagy in luteolin-induced apoptosis.

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