Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients – an Indicator of Decannulation Success? | Zendy

Paul Muhle | Zendy; Sonja SuntrupKrueger | Zendy; Stefan Bittner | Zendy; Tobias Ruck | Zendy; Inga Claus | Zendy; Thomas Marian | Zendy; J. Schröder | Zendy; Jens Minnerup | Zendy; Tobias Warnecke | Zendy; Sven G. Meuth | Zendy; Rainer Dziewas | Zendy

Open Access

Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients – an Indicator of Decannulation Success?

Author(s) -

Paul Muhle,

Sonja SuntrupKrueger,

Stefan Bittner,

Tobias Ruck,

Inga Claus,

Thomas Marian,

J. Schröder,

Jens Minnerup,

Tobias Warnecke,

Sven G. Meuth,

Rainer Dziewas

Publication year - 2017

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000482002

Subject(s) - saliva , dysphagia , medicine , stimulation , swallowing , stroke (engine) , anesthesia , prospective cohort study , substance p , reflex , gastroenterology , surgery , neuropeptide , receptor , mechanical engineering , engineering

Substance P (SP) is a neuropeptide, likely acting as a neurotransmitter in the pharyngeal mucosa enhancing the swallow and cough reflex. Pharyngeal Electrical Stimulation (PES) induces a temporary increase of salivary SP levels in healthy adults. Previous evidence suggests that post-stroke dysphagia is related to reduced SP levels. Here, we investigated the effects of PES on SP levels in severely dysphagic stroke patients and a possible link between increase of SP and treatment success.

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