Cyclophosphamide Pulse Therapy in Severe Refractory Crohn's Disease: A Retrospective Multicenter Case Series | Zendy

Florian Bär | Zendy; Thomas Krause | Zendy; Andreas Stallmach | Zendy; Niels Teich | Zendy; Christian Maaser | Zendy; Jochen Maul | Zendy; Ulf Helwig | Zendy; Klaus Fellermann | Zendy; Jürgen Büning | Zendy

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Cyclophosphamide Pulse Therapy in Severe Refractory Crohn's Disease: A Retrospective Multicenter Case Series

Author(s) -

Florian Bär,

Thomas Krause,

Andreas Stallmach,

Niels Teich,

Christian Maaser,

Jochen Maul,

Ulf Helwig,

Klaus Fellermann,

Jürgen Büning

Publication year - 2017

Publication title -

inflammatory intestinal diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9403

pISSN - 2296-9365

DOI - 10.1159/000481820

Subject(s) - refractory (planetary science) , cyclophosphamide , medicine , crohn's disease , series (stratigraphy) , retrospective cohort study , disease , surgery , chemotherapy , materials science , metallurgy , geology , paleontology

In Crohn's disease (CD) patients still remain refractory to current regimens, including biologicals. Previous data from small single-center studies indicated cyclophosphamide pulse therapy (CPT) to be effective for induction of remission at least in steroid-refractory cases. The aim of the present study was to study the efficacy and safety of CPT in mainly tumor necrosis factor (TNF)-refractory complicated CD patients.

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