Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion | Zendy

Hongmei Wang | Zendy; Ting Zhang | Zendy; Jiankang Huang | Zendy; Jingyan Xiang | Zendy; Jingjiong Chen | Zendy; Jianliang Fu | Zendy; Yuwu Zhao | Zendy

Open Access

Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion

Author(s) -

Hongmei Wang,

Ting Zhang,

Jiankang Huang,

Jingyan Xiang,

Jingjiong Chen,

Jianliang Fu,

Yuwu Zhao

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000481753

Subject(s) - inflammasome , proinflammatory cytokine , microglia , reactive oxygen species , oxidative stress , mitochondrial ros , chemistry , caspase 1 , superoxide dismutase , microbiology and biotechnology , edaravone , mitochondrion , pharmacology , biochemistry , biology , immunology , inflammation , receptor

Microglial activation is an important pathological feature in the brains of patients with Alzheimer's disease (AD), and amyloid-β (Aβ) peptides play a crucial role in microglial activation. In addition, edaravone (EDA) was recently shown to suppress oxidative stress and proinflammatory cytokine production in APPswePS1dE9 (APP/PS1) mice. However, the mechanism by which EDA inhibits the Aβ-induced proinflammatory response in microglia is poorly understood.

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