Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice | Zendy

Milena Doroszko | Zendy; Marcin Chruściel | Zendy; Joanna Stelmaszewska | Zendy; Tomasz Ślężak | Zendy; Adolfo RiveroMüller | Zendy; Artur Padzik | Zendy; Sławomir Anisimowicz | Zendy; Sławomir Wołczyński | Zendy; Ilpo Huhtaniemi | Zendy; Jorma Toppari | Zendy; Nafis A. Rahman | Zendy

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Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice

Author(s) -

Milena Doroszko,

Marcin Chruściel,

Joanna Stelmaszewska,

Tomasz Ślężak,

Adolfo RiveroMüller,

Artur Padzik,

Sławomir Anisimowicz,

Sławomir Wołczyński,

Ilpo Huhtaniemi,

Jorma Toppari,

Nafis A. Rahman

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000481718

Subject(s) - endocrinology , medicine , biology , adrenal cortex , zona reticularis , zona fasciculata , carcinogenesis , adrenocortical adenoma , cancer research , adenoma , zona glomerulosa , angiotensin ii , cancer , blood pressure

Physiological role of luteinizing hormone (LH) and its receptor (LHCGR) in adrenal remains unknown. In inhibin-α/Simian Virus 40 T antigen (SV40Tag) (inhα/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the growth of transcription factor GATA4 (GATA4)-positive adrenocortical tumors in a hyperplasia-adenoma-adenocarcinoma sequence.

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