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Thank you for your interest in our article titled “Albumin-bilirubin (ALBI) grade as part of the evidencebased clinical practice guideline for HCC of the Japan Society of Hepatology: a comparison with the liver damage and Child-Pugh classification” [1] . Huo et al. have sent an important message in their Letter to the Editor . Incorporation of models based on albumin-bilirubin (ALBI)/platelet-albumin-bilirubin (PALBI) grading, calculated using platelet count, serum albumin, and serum total bilirubin, into current HCC staging systems should be considered in order to refine their prognostic accuracy. There is no doubt that a new detailed assessment tool for hepatic function is needed in order to increase predictive accuracy for prognosis. We agree with their proposal. Liu et al. [2] reported that the accuracy of PALBI grade was superior to that of ALBI. It is well known that the prognosis of a patient with HCC depends both on hepatic functional reserve and tumor factors. Thus, in order to address the issues raised by Huo et al., we used modified Japan integrated staging (JIS) scoring, which is calculated based on Child-Pugh classification and tumor node metastasis stage (TNM) of the Liver Cancer Study Group of Japan, 6th edition, as well as ALBI-TNM (ALBI-T) [3] and PALBI-TNM (PALBI-T) to validate the comparison with ALBI and PALBI, after excluding 1 patient whose platelet count was unknown ( n = 3,494). Kaplan-Meyer curves for ALBI-T and PALBI-T are presented in Figure 1 , and they show similar stratification abilities for prognosis. The c-index was the same value as shown in ALBI-T and PALBI-T scoring, while Akaike’s information criterion (AIC) for ALBI-T was slightly better than that for PALBI-T ( Table 1 ). When AIC and c-index were assessed for each etiology, PALBI-T was better in HCC patients with the hepatitis C virus (HCV), while ALBI-T was better in those with hepatitis B virus (HBV), as well as those both without HBV and HCV. Thus, the prognostic predictive values may vary slightly for each etiology. HCV and HBV was detected in 64.6 and 14.5%, respectively, of the patients in our cohort, whereas HBV was the most common etiology in the report by Liu et al. [2] . Of note, it cannot be denied that ALBI grade calculated with only 2 factors, albumin and bilirubin, was not inferior to PALBI and presents a simpler tool for assessment of hepatic function. In fact, a good correlation between ALBI and PALBI scores was observed ( r = 0.820, 95% CI: 0.809–0.831, p < 0.0001). Moreover, there Published online: October 19, 2017

liver cancer

ALBI Score as a Novel Tool in Staging and Treatment Planning for Hepatocellular Carcinoma: Advantage of ALBI Grade for Universal Assessment of Hepatic Function