Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis | Zendy

Joana Torres | Zendy; Carolina Palmela | Zendy; Pedro Gomes de Sena | Zendy; Maria Pia Costa Santos | Zendy; C Gouveia | Zendy; Maria Helena Oliveira | Zendy; Ana Henriques | Zendy; Cecília M. P. Rodrigues | Zendy; Marília Cravo | Zendy; Paula Borralho | Zendy

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Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis

Author(s) -

Joana Torres,

Carolina Palmela,

Pedro Gomes de Sena,

Maria Pia Costa Santos,

C Gouveia,

Maria Helena Oliveira,

Ana Henriques,

Cecília M. P. Rodrigues,

Marília Cravo,

Paula Borralho

Publication year - 2017

Publication title -

ge portuguese journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 9

eISSN - 2341-4545

pISSN - 2387-1954

DOI - 10.1159/000481197

Subject(s) - farnesoid x receptor , medicine , ileum , inflammatory bowel disease , gastroenterology , immunohistochemistry , receptor , endocrinology , nuclear receptor , disease , chemistry , transcription factor , biochemistry , gene

Microscopic colitis (MC) is a chronic inflammatory bowel disease with unclear etiology. Bile acid (BA) malabsorption has been described in MC patients. Farnesoid X receptor (FXR) is the main BA receptor; FXR-mediated mechanisms prevent the noxious effects of BA accumulation, preserving the integrity of the intestinal epithelial barrier and preventing intestinal inflammation.

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