Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells | Zendy

Haifeng Lan | Zendy; Hong Wei | Zendy; Fan Pan | Zendy; Dongyang Qian | Zendy; Jianwei Zhu | Zendy; Bo Bai | Zendy

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Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells

Author(s) -

Haifeng Lan,

Hong Wei,

Fan Pan,

Dongyang Qian,

Jianwei Zhu,

Bo Bai

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480528

Subject(s) - cell cycle , angiogenesis , apoptosis , osteosarcoma , cancer research , cell growth , cell , flow cytometry , metastasis , mmp2 , cell migration , biology , mmp9 , viability assay , cancer , immunology , downregulation and upregulation , biochemistry , genetics , gene

Osteosarcoma is a malignant tumor associated with high mortality; however, no effective therapies for the disease have been developed. Several studies have focused on elucidating the pathogenesis of osteosarcoma and have aimed to develop novel therapies for the disease. Quercetin is a vital dietary flavonoid that has been shown to have a variety of anticancer effects, as it induces cell cycle arrest, apoptosis, and differentiation and is involved in cell adhesion, metastasis and angiogenesis. Herein, we aimed to investigate the effects of quercetin on osteosarcoma migration and invasion in vitro and in vivo and to explore the molecular mechanisms underlying its effects on osteosarcoma migration and invasion.

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