Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity | Zendy

Susann Fayyaz | Zendy; Lukasz Japtok | Zendy; Fabian Schumacher | Zendy; Dominik Wigger | Zendy; Tim J. Schulz | Zendy; Kathrin Haubold | Zendy; Erich Gulbins | Zendy; Heinz Völler | Zendy; Burkhard Kleuser | Zendy

Open Access

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

Author(s) -

Susann Fayyaz,

Lukasz Japtok,

Fabian Schumacher,

Dominik Wigger,

Tim J. Schulz,

Kathrin Haubold,

Erich Gulbins,

Heinz Völler,

Burkhard Kleuser

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480470

Subject(s) - lysophosphatidic acid , autotaxin , endocrinology , medicine , insulin receptor , insulin resistance , protein kinase b , glycogen synthase , receptor , lysophosphatidylcholine , insulin , insulin receptor substrate , biology , chemistry , signal transduction , biochemistry , phospholipid , membrane , phosphatidylcholine

Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX). ATX converts lysophosphatidylcholine to lysophosphatidic acid (LPA) and acts as the main producer of extracellular LPA. This bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA receptors (LPA1-6).

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