CD34+CD38-CD123+ Cells Are Present in Virtually All Acute Myeloid Leukaemia Blasts: A Promising Single Unique Phenotype for Minimal Residual Disease Detection | Zendy

Adhra AlMawali | Zendy; Avinash Daniel Pinto | Zendy; Shoaib AlZadjali | Zendy

Open Access

CD34+CD38-CD123+ Cells Are Present in Virtually All Acute Myeloid Leukaemia Blasts: A Promising Single Unique Phenotype for Minimal Residual Disease Detection

Author(s) -

Adhra AlMawali,

Avinash Daniel Pinto,

Shoaib AlZadjali

Publication year - 2017

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000480448

Subject(s) - cd38 , cd34 , interleukin 3 receptor , myeloid , stem cell , bone marrow , minimal residual disease , myeloid leukemia , medicine , immunology , haematopoiesis , leukemia , cancer research , biology , microbiology and biotechnology

In CD34-positive acute myeloid leukaemia (AML), the leukaemia-initiating event likely takes place in the CD34+CD38- cell compartment. CD123 has been shown to be a unique marker of leukaemic stem cells within the CD34+CD38- compartment. The aim of this study was to identify the percentage of CD34+CD38-CD123+ cells in AML blasts, AML CD34+CD38- stem cells, and normal and regenerating bone marrow CD34+CD38- stem cells from non-myeloid malignancies.

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