Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy | Zendy

Qianqian Dong | Zendy; Wenjuan Xing | Zendy; Feifei Su | Zendy; Xiangyan Liang | Zendy; Fei Tian | Zendy; Feng Gao | Zendy; Siwang Wang | Zendy; Haifeng Zhang | Zendy

Open Access

Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy

Author(s) -

Qianqian Dong,

Wenjuan Xing,

Feifei Su,

Xiangyan Liang,

Fei Tian,

Feng Gao,

Siwang Wang,

Haifeng Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480410

Subject(s) - autophagy , endothelial dysfunction , endocrinology , pi3k/akt/mtor pathway , medicine , downregulation and upregulation , protein kinase b , endothelial stem cell , microbiology and biotechnology , chemistry , biology , signal transduction , apoptosis , biochemistry , gene , in vitro

Obesity is a major risk for hypertension. Endothelial dysfunction contributes to increased peripheral vascular resistance and subsequent hypertension. Autophagy regulates endothelial function, however, whether autophagy is related to hypertension in obesity remains largely unclear. We wished to ascertain: (i) the role of autophagy in obesity-induced hypertension and the underlying mechanisms; (ii) if tetrahydroxystilbene glycoside (TSG) influences endothelial dysfunction and obesity-associated hypertension.

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