MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3 | Zendy

Ying Xu | Zendy; Yihua Bei | Zendy; Shutong Shen | Zendy; Jialiang Zhang | Zendy; Yichao Lu | Zendy; Junjie Xiao | Zendy; Xinli Li | Zendy

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MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3

Author(s) -

Ying Xu,

Yihua Bei,

Shutong Shen,

Jialiang Zhang,

Yichao Lu,

Junjie Xiao,

Xinli Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480371

Subject(s) - cell growth , microrna , transfection , western blot , vascular smooth muscle , luciferase , small interfering rna , cancer research , proliferating cell nuclear antigen , cell , microbiology and biotechnology , endothelial stem cell , chemistry , biology , cell culture , gene , smooth muscle , endocrinology , in vitro , biochemistry , genetics

Aberrant vascular smooth muscle cell (VSMC) proliferation plays an important role in the development of pulmonary artery hypertension (PAH). Dysregulated microRNAs (miRNAs, miRs) have been implicated in the progression of PAH. miR-222 has a pro-proliferation effect on VSMCs while it has an anti-proliferation effect on vascular endothelial cells (ECs). As the biological function of a single miRNA could be cell-type specific, the role of miR-222 in pulmonary artery smooth muscle cell (PASMC) proliferation is not clear and deserves to be explored.

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