mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation | Zendy

Shuzhen Li | Zendy; Zhenzhen Sun | Zendy; Guixia Ding | Zendy; Wei Gong | Zendy; Jing Yu | Zendy; Weiwei Xia | Zendy; Songming Huang | Zendy; Aihua Zhang | Zendy; Yue Zhang | Zendy; Zhanjun Jia | Zendy

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mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation

Author(s) -

Shuzhen Li,

Zhenzhen Sun,

Guixia Ding,

Wei Gong,

Jing Yu,

Weiwei Xia,

Songming Huang,

Aihua Zhang,

Yue Zhang,

Zhanjun Jia

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480369

Subject(s) - downregulation and upregulation , cell growth , cyclin d1 , prostaglandin e2 , prostaglandin e2 receptor , prostaglandin e , chemistry , gene silencing , prostaglandin , cyclooxygenase , cell cycle , microbiology and biotechnology , cancer research , apoptosis , receptor , endocrinology , medicine , biology , biochemistry , enzyme , gene , agonist

We previously reported that indoxyl sulfate (IS) could cause mesangial cell (MC) proliferation via a cyclooxygenase (COX)-2-dependent mechanism. However, the specific prostaglandin contributing to COX-2 effect on IS-induced MC proliferation remained unknown. Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation.

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