Involvement of S100A8/A9-TLR4-NLRP3 Inflammasome Pathway in Contrast-Induced Acute Kidney Injury | Zendy

Xuexian Tan | Zendy; Xiaohe Zheng | Zendy; Zena Huang | Zendy; Lin Jiaqiong | Zendy; Chuli Xie | Zendy; Yan Lin | Zendy

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Involvement of S100A8/A9-TLR4-NLRP3 Inflammasome Pathway in Contrast-Induced Acute Kidney Injury

Author(s) -

Xuexian Tan,

Xiaohe Zheng,

Zena Huang,

Lin Jiaqiong,

Chuli Xie,

Yan Lin

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480340

Subject(s) - inflammasome , iopromide , acute kidney injury , medicine , inflammation , tlr4 , apoptosis , kidney , pharmacology , cancer research , chemistry , biochemistry , contrast medium , radiology

Contrast-induced acute kidney injury (CIAKI) is a common cause of hospital-acquired acute kidney injury (AKI). S100A8/A9-TLR4-NLRP3 inflammasome pathway triggers inflammation, apoptosis and tissue injury in several AKI models. Nevertheless, the underlying mechanism of S100A8/A9-TLR4-NLRP3 inflammasome pathway in CIKAI is not clear. We aimed to investigate the possible role of S100A8/A9-TLR4-NLRP3 inflammasome in the pathophysiology of CIAKI.

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