Effect of the Diabetic Environment On the Expression of MiRNAs in Endothelial Cells: Mir-149-5p Restoration Ameliorates the High Glucose-Induced Expression of TNF-α and ER Stress Markers | Zendy

Jing Yuan | Zendy; Minghao Chen | Zendy; Qingyun Xu | Zendy; Jianxin Liang | Zendy; Ruixue Chen | Zendy; Ya Xiao | Zendy; Meixia Fang | Zendy; Liguo Chen | Zendy

Open Access

Effect of the Diabetic Environment On the Expression of MiRNAs in Endothelial Cells: Mir-149-5p Restoration Ameliorates the High Glucose-Induced Expression of TNF-α and ER Stress Markers

Author(s) -

Jing Yuan,

Minghao Chen,

Qingyun Xu,

Jianxin Liang,

Ruixue Chen,

Ya Xiao,

Meixia Fang,

Liguo Chen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480330

Subject(s) - microrna , microbiology and biotechnology , blot , apoptosis , flow cytometry , biology , transfection , umbilical vein , tumor necrosis factor alpha , in vitro , gene , immunology , biochemistry

This study aimed to screen microRNAs and their corresponding target genes that are associated with vascular injury in type two diabetes mellitus (T2DM), investigate the effects of differentially expressed miRNAs and their target genes on high glucose-induced vascular injury and establish the mechanism underlying these effects.

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