TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway | Zendy

Qing Chen | Zendy; Wei Yang | Zendy; Xixi Wang | Zendy; Xueru Li | Zendy; Shaopei Qi | Zendy; Yong Zhang | Zendy; MingQing Gao | Zendy

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TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway

Author(s) -

Qing Chen,

Wei Yang,

Xixi Wang,

Xueru Li,

Shaopei Qi,

Yong Zhang,

MingQing Gao

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480321

Subject(s) - smad , epithelial–mesenchymal transition , transforming growth factor , blot , vimentin , transforming growth factor beta , extracellular matrix , smad2 protein , signal transduction , fibronectin , fibrosis , cancer research , biology , microbiology and biotechnology , chemistry , medicine , downregulation and upregulation , immunology , immunohistochemistry , gene , biochemistry

Transforming growth factor-β1 (TGF-β1) plays a crucial role in chronic inflammation in various tissues, and is related to inflammation-caused organ fibrogenesis associated with the epithelial-mesenchymal transition (EMT) and the deposition of the extracellular matrix (ECM). However, the effect of TGF-β1 on bovine mammary epithelial cells (BMECs) with mastitis, and its mechanism, remain unknown.

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