VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway | Zendy

Jia Guo | Zendy; Congqun Lu | Zendy; Fangxing Zhang | Zendy; Haixia Yu | Zendy; Mengwen Zhou | Zendy; Meixia He | Zendy; Chunyan Wang | Zendy; Zhanzheng Zhao | Zendy; Zhangsuo Liu | Zendy

Open Access

VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway

Author(s) -

Jia Guo,

Congqun Lu,

Fangxing Zhang,

Haixia Yu,

Mengwen Zhou,

Meixia He,

Chunyan Wang,

Zhanzheng Zhao,

Zhangsuo Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480315

Subject(s) - calcitriol receptor , wnt signaling pathway , paricalcitol , endocrinology , diabetic nephropathy , proteinuria , medicine , sclerostin , podocyte , kidney , agonist , signal transduction , receptor , vitamin d and neurology , parathyroid hormone , biology , microbiology and biotechnology , secondary hyperparathyroidism , calcium

Diabetic nephropathy (DN) is a major cause of end-stage renal disease and proteinuria is one of the most prominent clinical manifestations. The expression of Vitamin D receptor (VDR) in patients with chronic kidney diseases was decreased, while VDR agonists could partially alleviate the proteinuria of DN in animal models. The present study was designed to determine the expression of VDR in renal tissues and its relationship with proteinuria the diabetic model db/db mice.

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