Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages | Zendy

Ping Chang | Zendy; Juan Liu | Zendy; Ying Yu | Zendy; Shao-Ye Cui | Zendy; Zhenhui Guo | Zendy; Guiming Chen | Zendy; Qiong Huang | Zendy; Zhanguo Liu | Zendy

Open Access

Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages

Author(s) -

Ping Chang,

Juan Liu,

Ying Yu,

Shao-Ye Cui,

Zhenhui Guo,

Guiming Chen,

Qiong Huang,

Zhanguo Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480217

Subject(s) - mapk/erk pathway , tumor necrosis factor alpha , p38 mitogen activated protein kinases , extracellular , microbiology and biotechnology , signal transduction , nf κb , proinflammatory cytokine , chemistry , cytokine , histone , cancer research , biology , inflammation , biochemistry , immunology , gene

This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research