Nitrosative Stress in the Rat Retina at the Onset of Streptozotocin-Induced Diabetes | Zendy

Ernesto Hernández-Ramírez | Zendy; Gustavo SánchezChávez | Zendy; Luis A. Estrella-Salazar | Zendy; Rocı́o Salceda | Zendy

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Nitrosative Stress in the Rat Retina at the Onset of Streptozotocin-Induced Diabetes

Author(s) -

Ernesto Hernández-Ramírez,

Gustavo SánchezChávez,

Luis A. Estrella-Salazar,

Rocı́o Salceda

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480007

Subject(s) - nitrotyrosine , retina , nitric oxide , medicine , endocrinology , streptozotocin , nicotinamide adenine dinucleotide phosphate , retinal , diabetes mellitus , nitric oxide synthase , glial fibrillary acidic protein , chemistry , biology , biochemistry , immunohistochemistry , oxidase test , neuroscience , enzyme

Nitric oxide is a multifunctional molecule that can modify proteins via nitrosylation; it can also initiate signaling cascades through the activation of soluble guanylate cyclase. Diabetic retinopathy is the leading cause of blindness, but its pathogenesis is unknown. Multiple mechanisms including oxidative-nitrosative stress have been implicated. Our main goal was to find significant changes in nitric oxide (NO) levels and determine their association with nitrosative stress in the rat retina at the onset of diabetes.

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