Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles | Zendy

Xiaolie He | Zendy; Yang Li | Zendy; Mei Wang | Zendy; Xizhen Zhuang | Zendy; Ruiqi Huang | Zendy; Rongrong Zhu | Zendy; Shilong Wang | Zendy

Open Access

Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles

Author(s) -

Xiaolie He,

Yang Li,

Mei Wang,

Xizhen Zhuang,

Ruiqi Huang,

Rongrong Zhu,

Shilong Wang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000480001

Subject(s) - behavioural despair test , cannabinoid receptor , curcumin , corticosterone , neun , pharmacology , neuroprotection , endocannabinoid system , chemistry , striatum , solid lipid nanoparticle , mtt assay , hippocampus , antidepressant , cannabinoid , dopamine , receptor , apoptosis , endocrinology , medicine , biochemistry , immunohistochemistry , drug , hormone , agonist

This study investigated the underlying mechanisms of the antidepressant effects of curcumin and dexanabinol-loaded solid lipid nanoparticles in corticosterone-induced cell and mice depression models.

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