Knockdown of Cxcl10 Inhibits Mesangial Cell Proliferation in Murine Habu Nephritis Via ERK Signaling | Zendy

Jie Gao | Zendy; Lingling Wu | Zendy; Yong Wang | Zendy; Shaoyuan Cui | Zendy; Shuwei Duan | Zendy; Zheyi Dong | Zendy; Zhe Feng | Zendy; Xiangmei Chen | Zendy

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Knockdown of Cxcl10 Inhibits Mesangial Cell Proliferation in Murine Habu Nephritis Via ERK Signaling

Author(s) -

Jie Gao,

Lingling Wu,

Yong Wang,

Shaoyuan Cui,

Shuwei Duan,

Zheyi Dong,

Zhe Feng,

Xiangmei Chen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000479914

Subject(s) - cxcl10 , microbiology and biotechnology , mapk/erk pathway , cell growth , cancer research , chemistry , signal transduction , biology , chemokine , immunology , inflammation , biochemistry

IFN-γ-inducible protein 10 (IP-10, CXCL10) has been widely demonstrated to be involved in chemotaxis, cell growth regulation and angiogenesis inhibition. It has been reported that CXCL10 expression is significantly increased in patients with MesPGN (Mesangial proliferative glomerulonephritis). However, the underlying mechanism of CXCL10 in MesPGN reminds unclear.

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