Dexmedetomidine Alleviates Hyperoxia-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation | Zendy

Qiuyue Zhang | Zendy; Di Wu | Zendy; Yang Yang | Zendy; Tingting Liu | Zendy; Hongyu Liu | Zendy

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Dexmedetomidine Alleviates Hyperoxia-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation

Author(s) -

Qiuyue Zhang,

Di Wu,

Yang Yang,

Tingting Liu,

Hongyu Liu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000479609

Subject(s) - hyperoxia , lung , medicine , pharmacology , tunel assay , in vivo , oxidative stress , inflammasome , reactive oxygen species , anesthesia , chemistry , immunology , endocrinology , inflammation , biology , immunohistochemistry , biochemistry , microbiology and biotechnology

Dexmedetomidine (Dex), a specific agonist of α2-adrenoceptor, has been reported to have extensive pharmacological effects. In this study, we focused on the protective effect of Dex on hyperoxia-induced acute lung injury and further explored its possible molecular mechanisms.

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