Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells | Zendy

Jilong Zou | Zendy; Yan Zhang | Zendy; Jiabing Sun | Zendy; Xiaoyan Wang | Zendy; Hualei Tu | Zendy; Shuo Geng | Zendy; Renhao Liu | Zendy; Yuxi Chen | Zendy; Zhenggang Bi | Zendy

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Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells

Author(s) -

Jilong Zou,

Yan Zhang,

Jiabing Sun,

Xiaoyan Wang,

Hualei Tu,

Shuo Geng,

Renhao Liu,

Yuxi Chen,

Zhenggang Bi

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000479537

Subject(s) - apoptosis , viability assay , autophagy , osteosarcoma , reactive oxygen species , annexin , cancer research , chemistry , caspase 3 , mtt assay , biology , microbiology and biotechnology , programmed cell death , biochemistry

Osteosarcoma is the predominant form of primary bone malignancy. Although the combinational application of neoadjuvant chemotherapy and surgical resection significantly increases the survival rate, the therapeutic outcome remains unsatisfactory. Deoxyelephantopin (DET), an active ingredient of Elephantopus scaber, has been reported to have an anti-tumor effect in recent publications. This study aimed to investigate whether DET has antineoplastic effects on osteosarcoma cells and its underlying mechanism.

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