Human Dendritic Cells with Th2-Polarizing Capacity: Analysis Using Label-Free Quantitative Proteomics | Zendy

Leonie Hussaarts | Zendy; Maria Mardalena Martini Kaisar | Zendy; Arzu Tuğçe Güler | Zendy; Hans Dalebout | Zendy; Bart Everts | Zendy; André M. Deelder | Zendy; Magnus Palmblad | Zendy; Maria Yazdanbakhsh | Zendy

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Human Dendritic Cells with Th2-Polarizing Capacity: Analysis Using Label-Free Quantitative Proteomics

Author(s) -

Leonie Hussaarts,

Maria Mardalena Martini Kaisar,

Arzu Tuğçe Güler,

Hans Dalebout,

Bart Everts,

André M. Deelder,

Magnus Palmblad,

Maria Yazdanbakhsh

Publication year - 2017

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000479512

Subject(s) - immune system , antigen , biology , microbiology and biotechnology , proteome , proteomics , immunology , antigen presentation , t cell , biochemistry , gene

Dendritic cells (DCs) are the sentinels of the immune system. Upon recognition of a pathogen, they mature and migrate to draining lymph nodes to prime and polarize T cell responses. Although it is known that helminths and helminth-derived molecules condition DCs to polarize T helper (Th) cells towards Th2, the underlying mechanisms remain incompletely understood.

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