Hypertrophy and Liver Function in ALPPS: Correlation with Morbidity and Mortality
Author(s) -
Danby Kang,
Erik Schadde
Publication year - 2017
Publication title -
visceral medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.598
H-Index - 17
eISSN - 2297-475X
pISSN - 2297-4725
DOI - 10.1159/000479477
Subject(s) - hepatectomy , liver failure , medicine , incidence (geometry) , liver function , muscle hypertrophy , gastroenterology , liver regeneration , surgery , resection , biology , mathematics , geometry , regeneration (biology) , microbiology and biotechnology
ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) was introduced with the promise to reduce posthepatectomy liver failure (PHLF) in extended hepatectomies but has higher morbidity and mortality rates compared to conventional methods of volume enhancement. There are few studies of the incidence of PHLF after ALPPS and little information on how to avoid PHLF by functional testing. It remains unclear what causes the compromise in liver function despite rapid volume gain and if any of the modifications proposed reduce the incidence of PHLF. This review summarizes published data on this topic.
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