Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy | Zendy

Stefano De Cillà | Zendy; Serena Farruggio | Zendy; Stela Vujosevic | Zendy; Giulia Raina | Zendy; Davide Filippini | Zendy; Valentina Gatti | Zendy; Nausicaa Clemente | Zendy; David Mary | Zendy; Diego Vezzola | Zendy; Giamberto Casini | Zendy; Luca Rossetti | Zendy; Elena Grossini | Zendy

Open Access

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Author(s) -

Stefano De Cillà,

Serena Farruggio,

Stela Vujosevic,

Giulia Raina,

Davide Filippini,

Valentina Gatti,

Nausicaa Clemente,

David Mary,

Diego Vezzola,

Giamberto Casini,

Luca Rossetti,

Elena Grossini

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000479441

Subject(s) - retinal pigment epithelium , occludin , tight junction , microbiology and biotechnology , paracellular transport , epithelium , biology , chemistry , fetal bovine serum , retinal , cell , permeability (electromagnetism) , biochemistry , genetics , membrane

he anti-vascular endothelial growth factors (VEGF), Aflibercept and Ranibizumab, are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apoptosis/autophagy in their antioxidant effects in human retinal pigment epithelium cells (RPE).

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