Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells | Zendy

HaiJian Sun | Zendy; Xuexue Zhu | Zendy; Wei Lin | Zendy; Yuetao Zhou | Zendy; Weiwei Cai | Zendy; Liying Qiu | Zendy

Open Access

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Author(s) -

HaiJian Sun,

Xuexue Zhu,

Wei Lin,

Yuetao Zhou,

Weiwei Cai,

Liying Qiu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478920

Subject(s) - tlr4 , ampk , endocrinology , inflammation , peroxisome proliferator activated receptor , tumor necrosis factor alpha , medicine , proinflammatory cytokine , receptor , lipopolysaccharide , protein kinase a , chemistry , biology , kinase , microbiology and biotechnology

Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis of atherosclerotic cardiovascular disease. Our previous studies had demonstrated that Vaccariae prevented high glucose or oxidative stress-triggered endothelial dysfunction in vitro. Very little is known about the potential effects of hypaphorine from Vaccariae seed on inflammatory response in endothelial cells.

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